Newly elected US President Joe Biden confronts enormous challenges in Africa with regard to reversing four years of the Donald Trump administration that was largely characterised by disdain, disinterest and derision toward the continent. The change of the guard in the White House come January 2021 is expected to herald a shift in tone and style toward the continent, which has always yearned for a prime spot on a crowded US foreign policy agenda. As I argued previously, there are high expectations of his presidency because most Africans regard democratic administrations to be more closely aligned to Africa’s concerns and interests. This essay analyses growing perceptions in Africa about the Biden administration and the possibilities for it meeting some of the continent’s objectives.