This chapter outlines the importance of postcolonial approaches for the study of Africa-EU relations. It contextualises such approaches in negotiation practices and outcomes of the EU proposed Economic Partnership Agreements (EPAs). Though academic literature on Africa-EU relations tends to define such relations as being asymmetrical, the politics around the negotiations of the EPAs through postcolonial lenses reveals contestations around the assumptions of such asymmetries. The very constitution of the EU was also a product of colonial legacy. The pursuits of European colonisers stretched throughout the world, but unlike the Americas and Asia, Africa held a special place in the efforts to construct European economic integration. Since the 1990s, Africa-EU relations have been based on neoliberal principles, with the EU considering trade and market liberalisation as central to poverty reduction while African leaders have also equated it with development.